Mechanical constraints and force transmission play an essential role in multicellular living organisms

They are regulating basic biological processes such as morphogenesis, tumor metastasis and tissue repair. Cell adhesions, coupled to the contractile cytoskeleton, are major sites of force transmission in cells. This mechanical coupling which enables cells to sense, signal, and respond to physical changes in the environment, has however been largely understudied. In this context, we are studying the cooperation between adhesion, mechanical and biochemical signaling for the adaptation of living cells to changes in their physical environment at various scales, from single molecules to tissues.

Adhesion complexes

We study the molecular bases of mechanosensing and mechanotransduction at cadherin-mediated adherens junctions.

Single cells

We study force sensing and mechanotransduction at integrin-mediated cell-extracellular matrix and cadherin-mediated cell-cell adhesions.

Cell assemblies

We study the collective behavior of cells in the context of tissue homeostasis but also in cell polarity and migration.

Tissues

We study how differentiating epithelial cells, integrating microenvironment cues, maintain cohesion, and establish and maintain apico-basal polarity.

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René-marc Mège & Benoît Ladoux

INSTITUT JACQUES MONOD
Université Paris Diderot / CNRS

15 rue Hélène Brion - Building Buffon
75205 Paris Cedex 13 - France

René-Marc Mège

Benoît Ladoux

+33 (0)157278071