Mechanical constraints and force transmission play an essential role in multicellular living organisms
They are regulating basic biological processes such as morphogenesis, tumor metastasis and tissue repair. Cell adhesions, coupled to the contractile cytoskeleton, are major sites of force transmission in cells. This mechanical coupling which enables cells to sense, signal, and respond to physical changes in the environment, has however been largely understudied. In this context, we are studying the cooperation between adhesion, mechanical and biochemical signaling for the adaptation of living cells to changes in their physical environment at various scales, from single molecules to tissues.
We study the molecular bases of mechanosensing and mechanotransduction at cadherin-mediated adherens junctions.
We study force sensing and mechanotransduction at integrin-mediated cell-extracellular matrix and cadherin-mediated cell-cell adhesions.
We study the collective behavior of cells in the context of tissue homeostasis but also in cell polarity and migration.
We study how differentiating epithelial cells, integrating microenvironment cues, maintain cohesion, and establish and maintain apico-basal polarity.
16-18 november 2020, Paris
The pathways leading from cells to embryo are highly complex. They involve among others steps of cell determination, patterning, cellular and organ morphogenesis, processes that are tightly controlled and coordinated in space and time. However, during the last decade, this field has benefited from major findings in the understanding of epigenetics, gene regulatory networks, mechanobiology, mechanisms of cell specification among others, and also from technical advances such as single cell omics. This symposium will address state-of-the-art research in this field, both in animals and plants. It will feature keynote and invited lectures, and selected short talks and posters. The symposium is organized at the initiative of the Multi-Organization Thematic Institute Cell Biology, Development & Evolution (ITMO – BCDE). See the composition of the Scientific Organization Committee. The meeting will take place on November 16 – 18, 2020 on the Université Paris-Diderot campus, located in the center of Paris, hosting around 180 participants, and providing opportunities for extensive interactions in a friendly and comfortable environment. Short talks will be selected by the organizers (applicants will be informed around October 1st) and two poster sessions will be organized. The call for abstracts will be open in the first quarter of 2020 (Deadline for sending your abstract: September 15th, 2020)
A 3 years founded post-doctoral position is open in the Ladoux-Mège Lab (http://ladoux-mege-lab.cnrs.fr), Institut Jacques Monod (https://www.ijm.fr), Université Paris Cité- CNRS.